The malleable brain: plasticity of neural circuits and behavior: A review from students to students

One of the most intriguing features of the brain is its ability to be malleable, allowing it to adapt continually to changes in the environment. Specific neuronal activity patterns drive long-lasting increases or decreases in the strength of synaptic connections, referred to as long-term potentiation (LTP) and long-term depression (LTD) respectively. Such phenomena have been described in a variety of model organisms, which are used to study molecular, structural, and functional aspects of synaptic plasticity. This review originated from the first International Society for Neurochemistry (ISN) and Journal of Neurochemistry (JNC) Flagship School held in Alpbach, Austria (Sep 2016), and will use its curriculum and discussions as a framework to review some of the current knowledge in the field of synaptic plasticity. First, we describe the role of plasticity during development and the persistent changes of neural circuitry occurring when sensory input is altered during critical developmental stages. We then outline the signaling cascades resulting in the synthesis of new plasticity-related proteins, which ultimately enable sustained changes in synaptic strength. Going beyond the traditional understanding of synaptic plasticity conceptualized by LTP and LTD, we discuss system-wide modifications and recently unveiled homeostatic mechanisms, such as synaptic scaling. Finally, we describe the neural circuits and synaptic plasticity mechanisms driving associative memory and motor learning. Evidence summarized in this review provides a current view of synaptic plasticity in its various forms, offers new insights into the underlying mechanisms and behavioral relevance, and provides directions for future research in the field of synaptic plasticity.Fil: Schaefer, Natascha. University of Wuerzburg; AlemaniaFil: Rotermund, Carola. University of Tuebingen; AlemaniaFil: Blumrich, Eva Maria. Universitat Bremen; AlemaniaFil: Lourenco, Mychael V.. Universidade Federal do Rio de Janeiro; BrasilFil: Joshi, Pooja. Robert Debre Hospital; FranciaFil: Hegemann, Regina U.. University of Otago; Nueva ZelandaFil: Jamwal, Sumit. ISF College of Pharmacy; IndiaFil: Ali, Nilufar. Augusta University; Estados UnidosFil: García Romero, Ezra Michelet. Universidad Veracruzana; MéxicoFil: Sharma, Sorabh. Birla Institute of Technology and Science; IndiaFil: Ghosh, Shampa. Indian Council of Medical Research; IndiaFil: Sinha, Jitendra K.. Indian Council of Medical Research; IndiaFil: Loke, Hannah. Hudson Institute of Medical Research; AustraliaFil: Jain, Vishal. Defence Institute of Physiology and Allied Sciences; IndiaFil: Lepeta, Katarzyna. Polish Academy of Sciences; ArgentinaFil: Salamian, Ahmad. Polish Academy of Sciences; ArgentinaFil: Sharma, Mahima. Polish Academy of Sciences; ArgentinaFil: Golpich, Mojtaba. University Kebangsaan Malaysia Medical Centre; MalasiaFil: Nawrotek, Katarzyna. University Of Lodz; ArgentinaFil: Paid, Ramesh K.. Indian Institute of Chemical Biology; IndiaFil: Shahidzadeh, Sheila M.. Syracuse University; Estados UnidosFil: Piermartiri, Tetsade. Universidade Federal de Santa Catarina; BrasilFil: Amini, Elham. University Kebangsaan Malaysia Medical Centre; MalasiaFil: Pastor, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; ArgentinaFil: Wilson, Yvette. University of Melbourne; AustraliaFil: Adeniyi, Philip A.. Afe Babalola University; NigeriaFil: Datusalia, Ashok K.. National Brain Research Centre; IndiaFil: Vafadari, Benham. Polish Academy of Sciences; ArgentinaFil: Saini, Vedangana. University of Nebraska; Estados UnidosFil: Suárez Pozos, Edna. Instituto Politécnico Nacional; MéxicoFil: Kushwah, Neetu. Defence Institute of Physiology and Allied Sciences; IndiaFil: Fontanet, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; ArgentinaFil: Turner, Anthony J.. University of Leeds; Reino Unid

A GIS-based fuzzy-analytic hierarchy process (F-AHP) for ecotourism suitability decision making: A case study of Babol in Iran

© 2020 Elsevier Ltd Managing ecotourism through appropriate zoning is critical for land use planning. This study is the first to integrate a geographic information system (GIS) with a Fuzzy-Analytic Hierarchy Process (F-AHP) to evaluate the relative importance of physical, natural, environmental, and socio-economic factors for determining the suitability of ecotourism sites. Eleven factors were selected through questionnaire-based surveying of 35 ecotourism and land management experts. F-AHP was applied to weight these factors in order to index and map the suitability of an Iranian case study area for ecotourism using GIS data. A reliable model for the identification of zone suitability was developed which revealed that landform and distance to stream, followed by temperature and elevation were the most important factors for calculating the suitability index. This paper provides useful insights into this novel application of a GIS-based F-AHP for ecotourism planning relevant for policy-makers, planners and practitioners

A GIS-based fuzzy-analytic hierarchy process (F-AHP) for ecotourism suitability decision making: A case study of Babol in Iran

Managing ecotourism through appropriate zoning is critical for land use planning. This study is the first to integrate a geographic information system (GIS) with a Fuzzy-Analytic Hierarchy Process (F-AHP) to evaluate the relative importance of physical, natural, environmental, and socio-economic factors for determining the suitability of ecotourism sites. Eleven factors were selected through questionnaire-based surveying of 35 ecotourism and land management experts. F-AHP was applied to weight these factors in order to index and map the suitability of an Iranian case study area for ecotourism using GIS data. A reliable model for the identification of zone suitability was developed which revealed that landform and distance to stream, followed by temperature and elevation were the most important factors for calculating the suitability index. This paper provides useful insights into this novel application of a GIS-based F-AHP for ecotourism planning relevant for policy-makers, planners and practitioners

A GIS-based fuzzy-analytic hierarchy process (F-AHP) for ecotourism suitability decision making: A case study of Babol in Iran

© 2020 Elsevier Ltd Managing ecotourism through appropriate zoning is critical for land use planning. This study is the first to integrate a geographic information system (GIS) with a Fuzzy-Analytic Hierarchy Process (F-AHP) to evaluate the relative importance of physical, natural, environmental, and socio-economic factors for determining the suitability of ecotourism sites. Eleven factors were selected through questionnaire-based surveying of 35 ecotourism and land management experts. F-AHP was applied to weight these factors in order to index and map the suitability of an Iranian case study area for ecotourism using GIS data. A reliable model for the identification of zone suitability was developed which revealed that landform and distance to stream, followed by temperature and elevation were the most important factors for calculating the suitability index. This paper provides useful insights into this novel application of a GIS-based F-AHP for ecotourism planning relevant for policy-makers, planners and practitioners

The energetic brain - A review from students to students

The past 20 years have resulted in unprecedented progress in understanding brain energy metabolism and its role in health and disease. In this review, which was initiated at the 14th International Society for Neurochemistry Advanced School, we address the basic concepts of brain energy metabolism and approach the question of why the brain has high energy expenditure. Our review illustrates that the vertebrate brain has a high need for energy because of the high number of neurons and the need to maintain a delicate interplay between energy metabolism, neurotransmission, and plasticity. Disturbances to the energetic balance, to mitochondria quality control or to glia-neuron metabolic interaction may lead to brain circuit malfunction or even severe disorders of the CNS. We cover neuronal energy consumption in neural transmission and basic ('housekeeping') cellular processes. Additionally, we describe the most common (glucose) and alternative sources of energy namely glutamate, lactate, ketone bodies, and medium chain fatty acids. We discuss the multifaceted role of non-neuronal cells in the transport of energy substrates from circulation (pericytes and astrocytes) and in the supply (astrocytes and microglia) and usage of different energy fuels. Finally, we address pathological consequences of disrupted energy homeostasis in the CNS.funded by the DFG (SFB779‐B14 and RTG2413 “SynAge” TP08), BMBF (IB‐049 “PrePLASTic”) and EU (MC‐ITN “ECMED”; LSA ESF ZS/2016/08/80645 “ABINEP”). C.I.S. is an editor for Journal of Neurochemistr